In the fast-growing world of aesthetic medicine, Plinest is gaining attention as one of the most advanced skin rejuvenation treatments in Malaysia. Developed and patented by Mastelli, a pioneer in regenerative biotechnology from Italy, this treatment uses polynucleotides (PNs) — purified DNA fragments extracted from Italian trout fish — to repair, hydrate, and strengthen the skin from within.
If you’ve heard about Rejuran or other skin boosters, Plinest is often described as the next generation. It focuses on deep repair and hydration, restoring your skin’s natural radiance without changing your facial features.
What Is Plinest?
Plinest is a bio-revitalizing injectable designed to improve overall skin quality. It contains highly purified polynucleotides (PNs) made with HPT — Highly Purified Technology, ensuring exceptional purity and biocompatibility. These natural molecules activate the body’s own healing response.
Once injected, they stimulate fibroblast activity, boosting collagen and elastin production for smoother, firmer, and more youthful skin. Unlike fillers that only add volume, Plinest works on a cellular and molecular level, rebuilding skin structure, improving elasticity, and providing long-lasting hydration.
How Does Plinest Work?
It uses PN-HPT (Polynucleotide Highly Purified Technology) developed through decades of research in tissue regeneration. When injected into the dermis layer, the PNs:
Regenerate fibroblasts and collagen to reverse visible signs of ageing.
Strengthen the extracellular matrix, improving firmness and texture.
Increase oxygen flow and nutrient absorption for overall skin health.
Provide antioxidant protection and long-lasting hydration.
This bio-revitalization process restores vitality to tired, aging skin, leaving it supple and radiant over time.
📊 Clinical Data Fact:
Plinest’s PN-HPT formula has been evaluated in over 100 published clinical studies worldwide. Research shows up to a 43% increase in skin hydration and a 32% improvement in elasticity within 4 weeks, confirming its ability to promote bio-revitalisation and reverse signs of ageing.
Benefits of Plinest Treatment
Plinest is one of the most versatile skin booster treatments available today. Its key benefits include:
✅ Natural rejuvenation without fillers or surgery.
✅ Improves elasticity while reducing fine lines and wrinkles.
✅ Deep skin hydration for dry or sensitive skin.
✅ Repairs sun damage and smooths acne scars.
✅ Reinforces the skin barrier for better protection.
✅ Promotes cell regeneration for long-term results.
Visible improvements usually appear within 3–4 weeks, with continued enhancement for several months.
Who Is Plinest Suitable For?
Plinest suits both men and women who want natural, long-lasting improvement in their skin. It’s ideal for those who:
Have dull, dehydrated, or sensitive skin.
Notice early signs of aging such as fine lines or loss of firmness.
Want to repair damaged skin or improve acne-scarred texture.
Prefer non-surgical rejuvenation with minimal downtime.
Wish to maintain youthful skin health from their mid-20s onward.
Plinest vs Rejuran: What’s the Difference?
| Feature | Plinest | Rejuran |
|---|---|---|
| Origin | Italy | South Korea |
| Main Ingredient | Polynucleotides (PNs) | Polynucleotides (PNs) |
| Technology | PN-HPT (Highly Purified Technology) | Standard PN formula |
| Function | Deep repair, hydration, antioxidant | Skin healing & repair |
| Best For | Sensitive, thin, or mature skin | General rejuvenation & scars |
Both treatments use polynucleotides, but Plinest’s HPT Technology ensures higher purity and improved tolerance, making it especially suitable for sensitive or mature skin types.
The Treatment Process
Consultation – Your practitioner evaluates your skin and sets expectations.
Preparation – Cleansing and application of a numbing cream.
Injection – Micro-injections deliver Plinest evenly into targeted areas (face, neck, or hands).
Recovery – Mild redness or small bumps may appear but fade within 24–48 hours.
Aftercare – Avoid sun exposure and harsh products; use sunscreen daily.
Most people undergo 3–4 sessions, spaced 3–4 weeks apart, followed by maintenance every 6–12 months.
Expected Results
Immediately: Skin feels hydrated and refreshed.
1–2 weeks: Notice improved smoothness and glow.
4–6 weeks: Reduction in fine lines and improved elasticity.
Long term: Ongoing collagen regeneration keeps skin firm and youthful.
Results develop gradually, delivering a healthy, natural finish without overfilled effects.
Side Effects and Safety
Plinest is CE-certified in Europe and clinically tested for safety. Mild, short-term effects such as redness or swelling are common and resolve within 1–2 days.
Because of its HPT purification process, allergic reactions are extremely rare. When performed by a licensed aesthetic practitioner, Plinest is considered safe for most patients.
How Much Does Plinest Cost in Malaysia?
The average cost of Plinest treatment in Malaysia ranges from RM1,500 to RM2,800 per session, depending on:
Treatment area (face, neck, or hands).
Number of sessions recommended.
Practitioner expertise and authenticity of products used.
Clinics often provide package options for multiple sessions, offering better long-term value.
Combination Treatments
To enhance bio-revitalization, Plinest can be combined with other non-surgical treatments such as:
HIFU (High Intensity Focused Ultrasound): For lifting and tightening.
Pico Laser: For pigmentation and texture improvement.
PRP (Platelet-Rich Plasma): To accelerate healing and glow.
Microneedling: To increase PN absorption and collagen production.
These combinations rejuvenate both surface and deep skin layers for a more complete transformation.
Frequently Asked Questions (FAQs)
1. Is it painful?
Discomfort is minimal. A numbing cream is used before treatment.
2. How many sessions are required?
Usually 3–4 sessions, one month apart, with maintenance every 6–12 months.
3. Can Plinest treat acne scars?
Yes. The PN-HPT technology stimulates fibroblast activity, helping smooth acne scars.
4. How long does the result last?
Results last 6–12 months depending on skin type, age, and aftercare.
5. Is there downtime?
Downtime is minimal — small injection bumps fade within 24–48 hours.
Conclusion
Plinest treatment in Malaysia is redefining non-surgical skin rejuvenation through its Polynucleotide Highly Purified Technology (PN-HPT). By repairing damaged skin, improving texture, and promoting bio-revitalization, it provides visible anti-aging results that last.
Developed and patented by Mastelli, and backed by over 100 published clinical studies, Plinest stands as one of the most trusted and scientifically proven treatments for skin repair, hydration, and overall skin health.
Whether you want to reverse signs of ageing, restore elasticity, or boost hydration, Plinest offers a safe and natural way to achieve smoother, brighter, and more youthful skin.