In the fast-growing world of aesthetic medicine, Rejuran has become one of the most talked-about treatments for natural skin healing and rejuvenation. Originating from South Korea, this innovative therapy uses polynucleotides (PN) derived from salmon DNA to stimulate skin repair, improve elasticity, and restore a youthful glow.
Now we will breaks down everything you need to know about Rejuran Healer, Rejuran S, Rejuran I, and Rejuran HB, backed by science and explained in simple terms.
What Is Rejuran?
Rejuran is an injectable skin booster treatment that contains polynucleotides (PNs). These are DNA fragments extracted from salmon, known for their high compatibility and safety in humans. When injected into the skin, these molecules trigger the body’s natural healing response, stimulating fibroblast activity, collagen production, and tissue regeneration.
Unlike hyaluronic acid (HA) fillers, which primarily add volume or hydration, Rejuran’s main purpose is skin repair and rejuvenation from within.
What Is Salmon DNA and How Does It Heal Skin from the Inside?
Salmon DNA is a natural source of polynucleotides (PNs)—biocompatible molecules that closely resemble human DNA. These PNs are highly safe and do not trigger allergic reactions, making them an ideal choice for regenerative therapies.
When injected into the skin, polynucleotides stimulate fibroblast activity, which enhances collagen and elastin production. They also improve microcirculation and cell turnover, helping repair damaged tissues, strengthen the skin barrier, and restore youthful elasticity. Instead of only hydrating the surface, salmon DNA works deep within the dermis, promoting long-term healing and visible skin rejuvenation.
Why Is It High Demand Nowadays?
Many people turn to Rejuran because it addresses skin concerns that creams, serums, and surface-level treatments cannot fix. Benefits include:
Improving skin texture and elasticity
Reducing fine lines and wrinkles
Enhancing skin hydration and radiance
Minimizing acne scars and enlarged pores
Supporting overall skin healing and repair
📊 Fact Check: A 2018 Korean clinical study found that patients receiving Rejuran injections showed significant improvement in skin elasticity and hydration within 4 weeks, with continued results over 12 weeks.
Types of Rejuran Treatments In Malaysia
Rejuran Healer
Often considered the foundation of the range, this treatment is designed for overall skin rejuvenation on the face and neck. It strengthens the skin barrier, restores natural elasticity, and deeply enhances hydration, leading to a smoother, healthier texture over time.
Rejuran S
Specially formulated to tackle acne scars, this option has a denser composition that allows it to lift depressed areas of the skin. By promoting active repair and encouraging collagen remodelling, it gradually smooths scarred tissue and refines uneven surfaces.
Rejuran I
Created for the delicate under-eye region, this gentle formulation addresses common concerns like fine lines, dark circles, and thinning skin. It stimulates collagen production in fragile tissue, helping the eye area appear brighter, firmer, and more youthful without overwhelming the skin.
Rejuran HB (Hydro Booster)
A unique blend of polynucleotides and hyaluronic acid, this version is ideal for restoring moisture levels while simultaneously repairing damaged cells. It is especially beneficial for individuals struggling with dryness, dullness, or a compromised skin barrier, leaving the complexion plump, luminous, and revitalized.
How Does It Work?
Rejuran is administered through micro-injections into the dermis layer of the skin. Once injected, the polynucleotides:
Stimulate fibroblasts → encourages collagen & elastin production.
Enhance skin barrier function → making skin stronger against pollution & aging.
Improve microcirculation → better nutrient and oxygen supply.
Repair damaged skin cells → leading to smoother, healthier skin.
Most patients require 3–4 sessions spaced 3–4 weeks apart, followed by maintenance every 6–12 months.
Benefits
Natural skin healing – not just superficial hydration.
Minimal downtime – small injection marks fade within 1–2 days.
Safe and biocompatible – salmon DNA has no allergic reactions in humans.
Long-lasting improvement – results can last 6–12 months with maintenance.
Rejuran vs. Other Skin Boosters
| Feature | Rejuran | Hyaluronic Acid Fillers | PRP (Platelet-Rich Plasma) |
|---|---|---|---|
| Main Ingredient | Polynucleotide (PN) | Hyaluronic Acid | Growth factors from blood |
| Function | Repair, rejuvenate | Hydration, volume | Healing, repair |
| Longevity | 6–12 months | 6–12 months | 3–6 months |
| Best For | Aging, scars, elasticity | Dryness, volume loss | Wound healing, scars |
Who Is Rejuran Suitable For?
Are in their late 20s and above, starting to see early aging signs.
Have acne scars or enlarged pores.
Want to improve fine lines and dullness.
Prefer natural rejuvenation instead of fillers or surgery.
⚠️ Note: Pregnant or breastfeeding women, and individuals with certain medical conditions, should avoid this treatment without medical clearance.
Safety, Risks, and Side Effects
It is generally safe when performed by a licensed and LCP-certified doctor. Common, mild side effects include:
Redness
Swelling at injection points
Small bumps (papules) that resolve in 24–48 hours
Serious side effects are rare but may occur if done by unqualified practitioners.
What to Expect After Treatment
Day 1–2: Small injection marks visible.
Week 1–2: Skin feels more hydrated and smoother.
Week 4 onwards: Visible improvement in texture, pores, and fine lines.
Long-term: Continued collagen stimulation with regular sessions.
How Much Does Rejuran Cost in Malaysia?
In Malaysia, the average cost of Rejuran treatments ranges between RM1,200 to RM2,500 per session, depending on the type used (Healer, S, I, or HB), the number of sessions required, and the clinic’s location. Most patients need 3–4 initial sessions spaced a month apart, followed by maintenance once or twice a year, so the overall investment can vary.
Let’s Compare With Profhilo: Which Works Better for Hydration?
When it comes to hydration, Profhilo generally has the upper hand. Made of pure, high-concentration hyaluronic acid, it spreads evenly under the skin to deliver deep, long-lasting moisture and a natural plumping effect. Patients often describe the result as a “glass skin” glow, making it one of the most effective injectable hydrators available.
On the other hand, the main strength lies in repair and regeneration. The polynucleotides (PN) from salmon DNA help improve skin elasticity, smooth scars, and strengthen the skin barrier. While the HB version (PN + HA) does provide added hydration, it still focuses more on healing and anti-aging.
FAQs
1. Is Rejuran painful?
Mild discomfort may occur, but numbing cream is applied before treatment to minimize pain.
2. How long do results last?
Typically 6–12 months, depending on skin condition and lifestyle.
3. How is Rejuran different from fillers?
Fillers add volume, while Rejuran heals and repairs skin from within.
4. Can it treat acne scars?
Yes, Rejuran S is specially designed for acne scar reduction.
5. What is the downtime?
Minimal—small injection bumps usually fade within 1–2 days.